{"id":2596,"date":"2026-01-06T11:27:35","date_gmt":"2026-01-06T04:27:35","guid":{"rendered":"https:\/\/naviva.com.vn\/?p=2596"},"modified":"2026-01-06T11:27:35","modified_gmt":"2026-01-06T04:27:35","slug":"vac-xin-thuy-dau-chung-mav-06-an-toan-va-hieu-qua-cho-tiem-chung-toan-cau","status":"publish","type":"post","link":"https:\/\/tbyt.devjournal.io.vn\/index.php\/vac-xin-thuy-dau-chung-mav-06-an-toan-va-hieu-qua-cho-tiem-chung-toan-cau\/","title":{"rendered":"V\u1eafc xin th\u1ee7y \u0111\u1eadu ch\u1ee7ng MAV\/06: An to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 cho ti\u00eam ch\u1ee7ng to\u00e0n c\u1ea7u"},"content":{"rendered":"

WHO c\u00f4ng nh\u1eadn ch\u1ee7ng MAV\/06 gi\u00fap \u0111a d\u1ea1ng h\u00f3a ngu\u1ed3n cung\u00a0v\u1eafc xin th\u1ee7y \u0111\u1eadu, n\u00e2ng cao t\u1ef7 l\u1ec7 ti\u00eam ch\u1ee7ng, g\u00f3p ph\u1ea7n b\u1ea3o v\u1ec7 tr\u1ebb em to\u00e0n c\u1ea7u.<\/span><\/strong><\/span><\/p>\n

\"\"<\/a><\/p>\n

Ng\u00e0y 21.11.2025, T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO) ch\u00ednh th\u1ee9c \u0111\u01b0a ch\u1ee7ng v\u1eafc xin th\u1ee7y \u0111\u1eadu MAV\/06 v\u00e0o t\u00e0i li\u1ec7u \u0111\u1ecbnh h\u01b0\u1edbng ch\u00ednh s\u00e1ch ti\u00eam ch\u1ee7ng to\u00e0n c\u1ea7u \u0111\u1ed1i v\u1edbi b\u1ec7nh th\u1ee7y \u0111\u1eadu, c\u00f4ng nh\u1eadn t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi ch\u1ee7ng Oka \u2013 n\u1ec1n t\u1ea3ng c\u1ee7a h\u1ea7u h\u1ebft v\u1eafc xin th\u1ee7y \u0111\u1eadu hi\u1ec7n nay [1].<\/span><\/p>\n

\u0110\u00e2y l\u00e0 l\u1ea7n \u0111\u1ea7u ti\u00ean m\u1ed9t ch\u1ee7ng do H\u00e0n Qu\u1ed1c ph\u00e1t tri\u1ec3n \u0111\u1ea1t m\u1ee9c c\u00f4ng nh\u1eadn n\u00e0y, m\u1edf r\u1ed9ng l\u1ef1a ch\u1ecdn v\u1eafc xin ch\u1ea5t l\u01b0\u1ee3ng cao, \u0111\u1eb7c bi\u1ec7t cho c\u00e1c qu\u1ed1c gia thu nh\u1eadp th\u1ea5p v\u00e0 trung b\u00ecnh.<\/span><\/p>\n

Ch\u1ee7ng MAV\/06 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ed9c l\u1eadp b\u1edfi GC Biopharma t\u1eeb cu\u1ed1i nh\u1eefng n\u0103m 1980, tr\u1ea3i qua nhi\u1ec1u l\u1ea7n gi\u1ea3m \u0111\u1ed9c l\u1ef1c tr\u00ean c\u00e1c d\u00f2ng t\u1ebf b\u00e0o ph\u00f4i ng\u01b0\u1eddi v\u00e0 chu\u1ed9t lang.<\/span><\/p>\n

Ch\u1ee7ng MAV\/06 c\u00f3 kh\u1ea3 n\u0103ng th\u00edch nghi t\u1ed1t v\u1edbi t\u1ebf b\u00e0o nu\u00f4i c\u1ea5y, \u0111\u1ed9 nh\u1ea1y nhi\u1ec7t th\u1ea5p v\u00e0 m\u1ee9c \u0111\u1ed9 gi\u1ea3m \u0111\u1ed9c l\u1ef1c \u1ed5n \u0111\u1ecbnh [2].<\/span><\/p>\n

Gi\u1ea3i tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 h\u1ec7 gen cho th\u1ea5y ch\u1ee7ng MAV\/06 thu\u1ed9c nh\u00e1nh 2, c\u00f9ng nh\u00f3m di truy\u1ec1n v\u1edbi ch\u1ee7ng Oka, c\u00f3 c\u1ea5u tr\u00fac gen v\u00e0 42 v\u1ecb tr\u00ed SNP \u0111\u1eb7c tr\u01b0ng li\u00ean quan gi\u1ea3m \u0111\u1ed9c l\u1ef1c, \u0111\u1ea3m b\u1ea3o \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a v\u1eafc xin [3].<\/span><\/p>\n

V\u1eafc xin s\u1ea3n xu\u1ea5t t\u1eeb ch\u1ee7ng MAV\/06 \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111a qu\u1ed1c gia v\u00e0 s\u1eed d\u1ee5ng h\u01a1n 30 tri\u1ec7u li\u1ec1u trong 30 n\u0103m t\u1ea1i H\u00e0n Qu\u1ed1c v\u00e0 h\u01a1n 20 n\u01b0\u1edbc \u1edf M\u1ef9 Latinh, ch\u00e2u \u00c1, trong \u0111\u00f3 c\u00f3 Vi\u1ec7t Nam, \u0111\u1ec1u kh\u00f4ng ghi nh\u1eadn c\u00e1c ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i nghi\u00eam tr\u1ecdng [4].<\/span><\/p>\n

V\u1eafc xin th\u1ebf h\u1ec7 m\u1edbi BARYCELA Inj., s\u1ea3n xu\u1ea5t t\u1eeb MAV\/06, kh\u00f4ng s\u1eed d\u1ee5ng kh\u00e1ng sinh, n\u00e2ng cao \u0111\u1ed9 an to\u00e0n v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c WHO-PQ t\u1eeb n\u0103m 2023.<\/span><\/p>\n

C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y MAV\/06 \u0111\u1ea1t t\u1ef7 l\u1ec7 chuy\u1ec3n \u0111\u1ed5i huy\u1ebft thanh 97-100%, hi\u1ec7u gi\u00e1 kh\u00e1ng th\u1ec3 cao v\u00e0 b\u1ec1n v\u1eefng. Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha III t\u1ea1i H\u00e0n Qu\u1ed1c v\u00e0 Th\u00e1i Lan x\u00e1c nh\u1eadn t\u00ednh sinh mi\u1ec5n d\u1ecbch kh\u00f4ng thua k\u00e9m so v\u1edbi v\u1eafc xin Oka [5].<\/span><\/p>\n

D\u1eef li\u1ec7u hi\u1ec7u qu\u1ea3 th\u1ef1c t\u1ebf t\u1ea1i H\u00e0n Qu\u1ed1c v\u00e0 M\u1ef9 Latinh ghi nh\u1eadn s\u1ed1 ca m\u1eafc gi\u1ea3m 60-80%, bi\u1ebfn ch\u1ee9ng gi\u1ea3m 92%, hi\u1ec7u qu\u1ea3 v\u1edbi ph\u00e1c \u0111\u1ed3 hai li\u1ec1u \u0111\u1ea1t >98%, t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1eafc xin Oka [6,7,8,9].<\/span><\/p>\n

Vi\u1ec7c WHO c\u00f4ng nh\u1eadn ch\u1ee7ng MAV\/06 gi\u00fap \u0111a d\u1ea1ng h\u00f3a ngu\u1ed3n cung v\u1eafc xin th\u1ee7y \u0111\u1eadu, gi\u1ea3m ph\u1ee5 thu\u1ed9c v\u00e0o m\u1ed9t ch\u1ee7ng duy nh\u1ea5t v\u00e0 n\u00e2ng cao t\u1ef7 l\u1ec7 ti\u00eam ch\u1ee7ng, g\u00f3p ph\u1ea7n b\u1ea3o v\u1ec7 tr\u1ebb em to\u00e0n c\u1ea7u.<\/span><\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/span><\/strong><\/span><\/p>\n

1. WHO position paper on varicella vaccines \u2013 November 2025<\/span><\/p>\n

2. Hwang, K. (1992) \u2018Marker Test for Attenuation of Varicella-Zoster Viruses Isolated in Korea\u2019, J. of Kor. Soc. Of Virology,22(2), pp. 105\u2013109.<\/span><\/p>\n

3. Moon, J.Y. et al.. Assessment of Attenuation of Varicella-Zoster Virus Vaccines Based on Genomic Comparison. J Med Virol 2023, 95.<\/span><\/p>\n

4. Lee, Y.H. et al. (2022) \u2018Global varicella vaccination programs\u2019, Clinical and Experimental Pediatrics, 65(12), pp. 555\u2013562.<\/span><\/p>\n

5. Choi, U.Y. et al. (2021) \u2018Immunogenicity and safety profiles of a new MAV\/06 strain varicella vaccine in healthy children: A multinational, Multicenter, randomized, double-blinded, active-controlled phase III study\u2019, Vaccine, 39(12), pp.1758\u20131764.<\/span><\/p>\n

6. Mar\u00eda L. et al. (2017) Varicella prevention in Costa Rica: impact of a one-dose schedule universal vaccination, Expert Review of Vaccines, 16:3, 229-234,<\/span><\/p>\n

7. Choi, J.-K. et al. (2019) \u2018Trends in varicella and herpes zoster epidemiology before and after the implementation of universal one-dose varicella vaccination over one decade in South Korea, 2003\u20132015\u2019, Human Vaccines & Immunotherapeutics, 15(11), pp.\u00a02554\u20132560<\/a>.<\/span><\/p>\n

8. Jung, J. et al. (2019) \u2018Epidemiological impact of the Korean National Immunization Program on Varicella incidence\u2019, Journal of Korean Medical Science, 34(7).<\/span><\/p>\n

9. Lee YH. et al.. The Protective Effectiveness of 2-Dose Varicella Vaccination in Children in Korea: A Case-control Study. Pediatr Infect Dis J. 2023 Aug 1;42(8):719-722.<\/span><\/p>\n

10. Kang, H.M. et al.. Safety of Interchanging the Live Attenuated MAV\/06 Strain and OKA Strain Varicella Vaccines in Children. Vaccines 2023, 11, 1442<\/span><\/p>\n

 <\/p>\n

Ngu\u1ed3n: B\u00e1o lao \u0111\u1ed9ng<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

WHO c\u00f4ng nh\u1eadn ch\u1ee7ng MAV\/06 gi\u00fap \u0111a d\u1ea1ng h\u00f3a ngu\u1ed3n cung\u00a0v\u1eafc xin th\u1ee7y \u0111\u1eadu, n\u00e2ng cao t\u1ef7 l\u1ec7 ti\u00eam ch\u1ee7ng, g\u00f3p ph\u1ea7n b\u1ea3o v\u1ec7 tr\u1ebb em to\u00e0n c\u1ea7u. Ng\u00e0y 21.11.2025, T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi (WHO) ch\u00ednh th\u1ee9c \u0111\u01b0a ch\u1ee7ng v\u1eafc xin th\u1ee7y \u0111\u1eadu MAV\/06 v\u00e0o t\u00e0i li\u1ec7u \u0111\u1ecbnh h\u01b0\u1edbng ch\u00ednh s\u00e1ch ti\u00eam ch\u1ee7ng […]<\/p>\n","protected":false},"author":3,"featured_media":2597,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[59],"tags":[],"class_list":["post-2596","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"acf":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/posts\/2596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/comments?post=2596"}],"version-history":[{"count":0,"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/posts\/2596\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/media?parent=2596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/categories?post=2596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tbyt.devjournal.io.vn\/index.php\/wp-json\/wp\/v2\/tags?post=2596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}